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March 3, 2026Current Alzheimer Research0 citations

Clinical and Medication Factors Associated with Cognitive Decline inDementia: A Healthcare Database Study

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CCChen-Chih ChungJCJia-Hung ChenLCLung Chan

Key Points

  • Cognitive decline was significantly affected by sex and medication use, particularly in dementia patients.
  • Antidementia medications were found to mitigate cognitive decline effectively during the analysis.
  • Only non-aspirin antiplatelet agents showed a link to increased cognitive decline in men diagnosed with dementia.
  • These findings highlight the importance of personalized treatment approaches for managing dementia effectively.

Abstract

In this large real-world cohort, sex and medication use were key determinants of cognitive decline in dementia. Antidementia medications mitigated decline. Notably, only non-aspirin antiplatelet agents, but not aspirin, were associated with greater cognitive decline in men., underscoring the need for personalized treatment approaches.

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Cite This Study

Chung et al. (2026) studied this question.

synapsesocial.com/papers/69a75ab2c6e9836116a20dc4https://doi.org/10.2174/0115672050420540251027112136
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