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March 3, 2026Frontiers in Endocrinology0 citationsOpen Access

TyG index and MAFLD severity are associated with subclinical LV dysfunction in T2DM patients: a cross−sectional study

XHXiangsui HuHCHanwei ChenZWZiying Wang

Key Points

  • Subclinical LV dysfunction correlates with the TyG index, indicating its role as an early warning sign.
  • The Fib-4 index, together with the TyG index, acts as a powerful predictor of heart issues in T2DM patients.

Structured PICO

Are the Fib-4 index and TyG index associated with subclinical LV dysfunction in T2DM patients?

P
Population
Patients with type 2 diabetes mellitus (T2DM)
I
Intervention
Assessment of Fib-4 index, TyG index, and MAFLD severity
O
Outcome
Subclinical LV dysfunction (SLVD)surrogate

Combined assessment of Fib-4 and TyG indices provides a simple, non-invasive tool for early risk stratification of subclinical LV dysfunction in T2DM patients.

Abstract

Fib-4 index and TyG index are independent predictors of SLVD in T2DM, and their coexistence exerts a synergistic effect. Combined assessment provides a simple, non-invasive tool for early risk stratification, highlighting the clinical importance of the liver-heart axis in identifying SLVD.

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Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/69a75accc6e9836116a2115chttps://doi.org/10.3389/fendo.2025.1749989
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