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March 3, 2026Translational Lung Cancer Research0 citationsOpen Access

Retrospective study on the tolerability using a four-cycle completion in elderly patients with extensive-stage small-cell lung cancer: a body mass index-based analysis

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YTYuto TerashimaSTSusumu TakeuchiYIYusuke Ishibashi

Key Points

  • Decreased tolerability to anti-PD-L1 therapy correlates with low BMI in elderly patients.
  • The study found that poor performance status independently affects tolerability outcomes.
  • Analysis explored treatment responses and tolerability in elderly patients with extensive-stage small-cell lung cancer.
  • Incorporating geriatric assessments may enhance treatment decisions and patient outcomes.

Abstract

Low BMI and poor performance status were independently associated with decreased tolerability to anti-PD-L1 antibody combined with platinum-etoposide in elderly patients with ES-SCLC. These findings underscore the importance of incorporating geriatric assessments into treatment decision-making for this population.

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Cite This Study

Terashima et al. (2026) studied this question.

synapsesocial.com/papers/69a75aedc6e9836116a2161bhttps://doi.org/10.21037/tlcr-2025-1058
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