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Synapse
March 3, 2026Diabetology & Metabolic Syndrome0 citationsOpen Access

miR-4687-5p promotes the progression of diabetic retinopathy by targeting SIRT2 to mediate inflammatory responses

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YZYuanlong ZhangSLSui LiuLWLichun Wei

Key Points

  • Progression of diabetic retinopathy is promoted by miR-4687-5p targeting SIRT2, enhancing inflammation.
  • The findings suggest that miR-4687-5p could serve as a valuable biomarker for early detection of diabetic retinopathy.
  • Analysis indicates the manipulation of miR-4687-5p may open new avenues for therapeutic interventions in diabetic retinopathy.
  • Highlighting this pathway opens opportunities for targeted treatments to correct inflammatory responses.

Abstract

miR-4687-5p is expected to become a biomarker for the early diagnosis of DR and a potential therapeutic target.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69a75b2ac6e9836116a21fc0https://doi.org/10.1186/s13098-026-02097-0
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