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March 3, 2026Organic Chemistry FrontiersOpen Access

Densely-functionalized bicyclic cyclopentanones by combined photoinduced 6- endo-trig Giese additions and mild aldol cyclizations

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Authors

JVJúlia Viñas-LóbezNSNicolas SelletBFBibiana Fabri

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Overview

Observational analysis reveals effective synthesis of bicyclic ketones, indicating new pathways in organic chemistry.

Key Points

  • Bicyclic ketones are synthesized from malonate-derived enol ethers using photoredox methods, achieving stereocontrol.
  • The photoredox-enabled approach employs two activation pathways involving acridinium orange and Hantzsch ester under specific wavelengths.
  • Mechanistic studies confirm the same radical intermediates produced through two different conditions using electrochemistry and UV-Vis analysis.
  • This method allows for diverse ring sizes and trans-fused product formation, suggesting advancements in synthetic organic chemistry.

Cite This Study

Viñas-Lóbez et al. (2026) studied this question.

synapsesocial.com/papers/69a75b5dc6e9836116a22932https://doi.org/10.1039/d5qo01635e
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