Genomic features associated with sustained mammalian transmission of avian influenza A viruses

Key Points

• Sustained mammalian transmission of avian influenza A viruses is influenced by specific genomic features.
• Key evidence shows significant variation in infectivity based on genomic traits across multiple viral strains.
• Analysis examines viral pathogenesis mechanisms by assessing genomic sequences from diverse avian influenza A viruses.
• Findings highlight the need for monitoring avian strains to predict potential zoonotic outbreaks and human health risks.