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March 3, 2026Annals of Surgical Oncology0 citationsOpen Access

Adenosquamous Carcinoma of the Pancreas: Outcomes of a Multicenter European Study (ADESQUPAN Project)

JRJose Manuel RamiaCVCelia VillodreDGDimitrios Giakoustidis

Key Points

  • Survival rates for patients undergoing surgery for adenosquamous carcinoma are very low, with only 10% surviving five years.
  • Patients undergoing T4 tumor resections have particularly poor outcomes, especially those with significant comorbidities.
  • Adjuvant chemotherapy is recommended after resection, but is often not given due to severe postoperative complications.
  • The findings emphasize the need for careful patient selection and risk assessment prior to surgical intervention.

Abstract

Patients who undergo resection for ASCP experience very low 5-year survival rates (10%). It is advisable to avoid resecting T4 tumors in patients with significant comorbidities or R2 resections. Additionally, failure to provide adjuvant chemotherapy, often due to severe postoperative complications, further deteriorates the prognosis.

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Cite This Study

Ramia et al. (2026) studied this question.

synapsesocial.com/papers/69a75b76c6e9836116a22ccehttps://doi.org/10.1245/s10434-025-19051-5
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