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March 3, 2026Clinical and Translational Medicine0 citationsOpen Access

DNTTIP1 drives leukaemogenesis through MiDAC‐mediated epigenetic silencing of BMF

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RXRuolin XiuYMYuzhu MaSLSi Li

Key Points

  • Leukaemogenesis is driven by DNTTIP1 through MiDAC-mediated epigenetic silencing of BMF, leading to cell death inhibition.
  • DNTTIP1 is notably overexpressed in acute leukaemia patients, correlating with a poorer prognosis.
  • Pharmacological disruption of the DNTTIP1-HDAC1/2-BMF axis effectively impairs leukaemogenesis, providing potential treatment avenues.
  • Epigenetic alterations in this pathway highlight significant therapeutic targets for future studies in acute leukaemia.

Abstract

DNTTIP1 is overexpressed in acute leukaemia and associated with poor prognosis. DNTTIP1 acts as a scaffold for the MiDAC complex, recruiting HDAC1/2 to silence BMF and inhibit leukaemic cell death. Pharmacological disruption of the DNTTIP1-HDAC1/2-BMF axis impairs leukaemogenesis.

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Cite This Study

Xiu et al. (2026) studied this question.

synapsesocial.com/papers/69a75bdcc6e9836116a23f05https://doi.org/10.1002/ctm2.70603
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