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March 3, 2026Open Access

The average does not represent the individual: White matter variability across the brain, across the population, and across the lifespan

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Authors

KSKurt SchillingLDLilit DulyanECEva Guzmán Chacón

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Overview

This observational analysis finds significant variability in white matter across the lifespan, suggesting individualized brain structures.

Key Points

  • White matter variability affects individual brain structure and function, impacting cognitive abilities and neurological health.
  • Participants across several age groups exhibited marked differences in white matter integrity, highlighting a range of 20% variability.
  • Observational analysis utilized neuroimaging techniques to assess white matter across diverse populations, including younger and older individuals.
  • Findings may imply a need for personalized approaches in neuroscience, particularly regarding aging and cognitive decline.

Cite This Study

Schilling et al. (2026) studied this question.

synapsesocial.com/papers/69a75c1bc6e9836116a24977https://doi.org/10.21203/rs.3.rs-8654078/v1
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