Mutations in HIV-1 integrase do not provide resistance to anti-integrase drugs, impacting treatment strategies.
Key observations indicate that these insertions are detrimental to viral replication efficiency.
The assessment involves analyzing genetic changes in the integrase-coding region in HIV-1 cases.
These findings suggest a need for further investigation into the implications for patient management.
Abstract
Our study has revealed that the mutations observed in people living with HIV-1 do not confer resistance to anti-integrase compounds but are detrimental to viral replication.