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March 3, 2026SHILAP Revista de lepidopterologíaOpen Access

Altered genome induced immune response of iPSCs

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Authors

JOJordi Requena OseteBPBelén Alvarez PalomoMEMichael J. Edel

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Overview

Observational analysis demonstrates enhanced immune response due to genomic alterations in pluripotent cells, suggesting clinical implications.

Key Points

  • Altered genome in pluripotent cells may activate immune responses, impacting cell therapy.
  • Approximately 34% of iPSC lines exhibit amplifications in specific chromosomal regions like 20q.
  • Analysis using high-density DNA methylation arrays identifies gene copy number variations in these cell lines.
  • Significant genomic alterations may create immune dysregulation, underscoring clinical relevance.

Cite This Study

Osete et al. (2026) studied this question.

synapsesocial.com/papers/69a75cf1c6e9836116a263f3https://doi.org/10.3389/fimmu.2026.1751499
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