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March 3, 2026Frontiers in Psychiatry1 citationsOpen Access

Promethazine-induced neuroleptic malignant syndrome under general anesthesia: a case report

PLPeng LiuZLZhi-Min Liao

Key Points

  • Neuroleptic malignant syndrome can occur from standard drug dosages, according to this case.
  • Key indicators for neuroleptic malignant syndrome diagnosis rely heavily on clinical symptoms.
  • Observational analysis of a single case reveals vital lessons for anesthesia practices regarding drug safety.
  • Highlighting the need for prompt identification can significantly improve patient outcomes in anesthesia settings.

Abstract

This case illustrates that due to individual variations, even standard drug dosages may induce neuroleptic malignant syndrome (NMS). Notably, NMS lacks specific laboratory findings, and its diagnosis must rely on clinical symptoms to avoid delays in early identification and treatment.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69a75cfcc6e9836116a26550https://doi.org/10.3389/fpsyt.2026.1700644
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