Multi-omics reveals hepatotoxic mechanisms and key toxic components of Polygoni Multiflori Radix and its processed products

Key Points

• Hepatotoxicity mechanisms reveal critical pathways of toxicity in polygoni multiflori radix and its processed products.
• Utilizing multi-omics, the analysis identified specific biomarkers linked to the toxic response in liver tissues.
• Metabolomics assessments indicated significant alterations in liver function markers related to polysaccharide and alkaloid content.
• These findings highlight the importance of safety evaluations for herbal products, underscoring potential hepatotoxic risks.