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March 3, 2026SHILAP Revista de lepidopterología0 citationsOpen Access

Identification of CXCL12 as a key gene of trophoblast and endometrial stromal cell decidualization in pregnancy via scRNA-seq and experimental validation

XSXianli SunHYHaimei YangZLZhe Leng

Key Points

  • CXCL12 significantly enhances proliferation and migration in trophoblast cells with implications for pregnancy outcomes.
  • The study observes the involvement of the CXCL12/CXCR4 axis in reproductive health issues like recurrent miscarriage, with potential treatment avenues.
  • Experimental validation paired with single-cell RNA sequencing provides robust insights into cellular interactions during decidualization.
  • Findings highlight CXCL12 as a potential therapeutic target, warranting further studies to explore its role in pregnancy-related complications.

Abstract

CXCL12 promotes the proliferation, migration, and invasion ability of trophoblast cells in vitro and promotes the decidualization of endometrial stromal cells. The downregulation of the CXCL12/CXCR4 axis may be involved in the occurrence and development of RM. Thus, this study provides experimental clues for exploring potential therapeutic approaches related to CXCL12.

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Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/69a75e71c6e9836116a290e5https://doi.org/10.3389/fmolb.2026.1768015
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