PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 3, 20260 citationsOpen Access

Single cell profiling reveals GSM-15606 attenuates air pollution-induced inflammation and preserves hippocampal neurogenesis

MSMohammad ShariqWPWanqing PanXCXiran Chen

Key Points

  • Air pollution activates inflammatory pathways, hindering neurogenesis in the hippocampus, which affects cognitive abilities.
  • GSM-15606 reverses inflammation in glial cells without affecting neural stem cells, indicating targeted cellular effects.
  • Analysis of the protective role of GSM-15606 against pollution-induced damage reveals potential for therapeutic interventions.
  • This approach highlights the importance of specific cellular mechanisms, though it requires further validation in clinical settings.

Abstract

AirPoll activates divergent inflammatory pathways across hippocampal cell populations and suppresses neurogenesis. Targeting inflammation with GSM-15606 selectively reverses glial but not neural stem cell responses, highlighting cell-type-specific mechanisms and potential therapeutic pathways to mitigate pollution-related cognitive vulnerability. These results support GSM-15606 as a protective agent against AirPoll-induced hippocampal dysfunction and amyloidogenic stress.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Shariq et al. (2026) studied this question.

synapsesocial.com/papers/69a75e88c6e9836116a29366https://doi.org/10.64898/2026.01.27.702094
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Air pollution amyloidogenesis is attenuated by the gamma‐secretase modulator GSM‐156062024 · 7 citations
  2. 2Long-term Air Pollution Exposure Is Associated with Neuroinflammation, an Altered Innate Immune Response, Disruption of the Blood-Brain Barrier, Ultrafine Particulate Deposition, and Accumulation of Amyloid β-42 and α-Synuclein in Children and Young Adults2008 · 938 citations
  3. 3Phosphorylation of Lysophosphatidylcholine Acyltransferase 2 at Ser34 Enhances Platelet-activating Factor Production in Endotoxin-stimulated Macrophages2010 · 59 citations
  4. 4Neurotoxic effects of air pollution: an urgent public health concern2023 · 45 citations
  5. 5Synergistic Signaling in Fetal Brain by STAT3-Smad1 Complex Bridged by p3001999 · 864 citations