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March 3, 2026Frontiers in Pediatrics0 citationsOpen Access

Evaluation of the classification performance and cost-effectiveness of classification criteria in children with systemic lupus erythematosus

SÖSemanur ÖzdelAGAlejandro G Gonzalez GarayMVMiguel Ángel Villasís-Keever

Key Points

  • SLICC-2012 criteria provide the highest sensitivity for classifying systemic lupus erythematosus.
  • ACR-1997 criteria are identified as the most cost-effective option under specialized conditions.
  • Higher sensitivity of SLICC-2012 criteria may enhance early referrals for treatment.
  • Cost-effectiveness varies, influencing the choice of criteria based on healthcare settings.

Abstract

The SLICC-2012 criteria were the most sensitive for the classification of SLE, but not the most cost-effective. ACR-1997 remains the most cost-effective tool in specialized settings; however, the higher sensitivity of SLICC-2012 supports its use to improve early referral.

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Cite This Study

Özdel et al. (2026) studied this question.

synapsesocial.com/papers/69a75edac6e9836116a29d2chttps://doi.org/10.3389/fped.2026.1745252
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