Prospective observational study of magnetic resonance imaging in anti-CD19 CAR T-cell-associated neurotoxicity

Key Points

• Neurotoxicity associated with anti-CD19 CAR T-cell therapy was observed through MRI scans, indicating potential risks.
• MRI findings revealed neurotoxicity in patients receiving CAR T-cell therapy for hematologic malignancies, with notable brain changes.
• Observational study design was employed to analyze neuroimaging data from subjects treated with CAR T-cells, shedding light on treatment effects.
• Highlighting the need for careful monitoring of neurotoxicity in CAR T-cell therapy, emphasizing the role of MRI in detecting neurological effects.