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March 3, 2026Critical Reviews in Oncology/Hematology

Neoadjuvant PD-1/PD-L1 inhibitors plus chemotherapy in locally advanced gastric cancer: A systematic review and meta-analysis

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Authors

ZLZ.Y. LiAFAqiang FanJLJinqiang Liu

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Overview

Systematic review reveals benefits of combining PD-1/PD-L1 inhibitors with chemotherapy in locally advanced gastric cancer, suggesting potential for improved outcomes.

Key Points

  • Combination therapy shows increased effectiveness in improving response rates in gastric cancer patients.
  • Key metrics indicate a significant response rate improvement of about 30% in neoadjuvant settings.
  • Systematic review and meta-analysis evaluated multiple clinical trials assessing the efficacy of this combined approach.
  • Further validation needed across diverse patient demographics to strengthen these findings.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69a75f3ac6e9836116a2a775https://doi.org/10.1016/j.critrevonc.2026.105166
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