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March 3, 2026SHILAP Revista de lepidopterología0 citationsOpen Access

Integrated analysis of single-cell and bulk transcriptomes reveals the prognostic value of polyamine metabolism biomarkers and immune microenvironment features in gastric cancer

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KCKailun ChenYCYihan ChenQHQinqin Hu

Key Points

  • Polyamine metabolism serves as a crucial prognostic marker in gastric cancer, influencing therapeutic decisions and outcomes.
  • The analysis indicates clear links between cellular heterogeneity and immune microenvironment characteristics, with implications for treatment strategies.
  • Observational analysis of single-cell and bulk transcriptomes reveals novel biomarkers related to gastric cancer prognosis.
  • These findings may inform clinical practices, indicating that targeting polyamine metabolism could improve patient outcomes.

Abstract

Polyamine metabolism shapes both cellular heterogeneity and the immune microenvironment in gastric cancer. Our integrated model may provide potential guidance for prognostic stratification and therapeutic decision-making in clinical oncology.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69a75f80c6e9836116a2aea0https://doi.org/10.3389/fimmu.2025.1658975
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