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March 3, 2026American Heart Journal0 citationsOpen Access

Association between atherosclerosis and atrial fibrillation progression in patients with paroxysmal atrial fibrillation: Data from the RACE V study

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DBDawid K. BaronVWVanessa WeberndorferHCHarry J.G.M. Crijns

Key Points

  • Atrial fibrillation progression was associated with atherosclerosis in 65% of patients, indicating a potential link.
  • Adjustments for established risk factors confirmed the relevance of atherosclerosis in determining AF outcomes over time.

Structured PICO

Is atherosclerosis associated with atrial fibrillation progression in patients with paroxysmal atrial fibrillation?

P
Population
Patients with paroxysmal atrial fibrillation (from the RACE V study)
I
Intervention
Presence of atherosclerosis
C
Comparator
Absence of atherosclerosis
O
Outcome
Atrial fibrillation progression

Atherosclerosis is an independent determinant of AF progression in patients with paroxysmal AF, highlighting a potential direct role of vascular disease in atrial remodeling.

Abstract

In patients with paroxysmal AF, 65% of patients had atherosclerosis. Atherosclerosis was a determinant of AF progression after adjustment for established risk factors and comorbidities, suggesting that vascular disease may contribute directly to atrial remodelling and arrhythmia persistence.

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Cite This Study

Baron et al. (2026) studied this question.

synapsesocial.com/papers/69a75ff8c6e9836116a2c570https://doi.org/10.1016/j.ahj.2026.107366
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