Case control study investigates gene polymorphisms and attachment loss in periodontitis, indicating potential risks.
Key Points
Individuals with advanced attachment loss showed higher frequencies of CT and TT genotypes in the NLRP3 rs4612666 polymorphism, indicating a potential risk.
A logistic regression analysis highlighted significant associations with attachment loss, especially in various genetic models involving NLRP3 rs4612666.
Polymorphisms in NLRP3, AIM2, and IFI16 genes were genotyped using real-time polymerase chain reaction—no significant differences in distribution among groups observed overall.
Results highlight that while some associations were found in specific models, overall susceptibility risks were not confirmed in the tested population.