Abnormal bone homeostasis in GDD is linked to glucose metabolism alterations mediated by AMPK activation.
The findings suggest that AMPK plays a crucial role in the pathophysiology of GDD-related bone issues.
This analysis emphasizes the importance of metabolic pathways, particularly glucose metabolism, in GDD.
Therapeutic strategies targeting AMPK-dependent glucose metabolism may improve conditions related to GDD.
Abstract
We highlighted the critical role of glucose metabolic distemperedness mediated by AMPK activation in GDD, which developing a potential therapeutic strategy targeted for treatment of GDD.