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March 3, 2026BMC Infectious Diseases0 citationsOpen Access

Disseminated Histoplasmosis Diagnosed by mNGS in Immunocompetent Patient

Disseminated histoplasmosis diagnosed by mNGS in a middle-aged immunocompetent patient: a case report and literature review

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Authors

LLLianbao LiTCTaigui ChenJLJing Li

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Overview

Case report reveals challenges diagnosing disseminated histoplasmosis in an immunocompetent individual, suggesting clinical awareness is needed.

Key Points

  • Disseminated histoplasmosis was diagnosed in an immunocompetent patient with non-specific symptoms.
  • Diagnosis was achieved through metagenomic next-generation sequencing, illustrating innovative techniques for detection.
  • A literature review included cases from 2021 to 2025, highlighting the rarity of this condition in immunocompetent individuals.
  • Findings suggest the need for greater clinical awareness to prevent misdiagnosis of disseminated histoplasmosis.
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Li et al. (2026) studied this question.

synapsesocial.com/papers/69a76068c6e9836116a2d210https://doi.org/10.1186/s12879-026-12692-1
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