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March 3, 2026Maturitas1 citationsOpen Access

Dietary intake of live microbes is inversely associated with fatigue and modified by serum folate among adults aged 40 years or more

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GBGalya BigmanAKAmber S. KlecknerYLYuanyuan Li

Key Points

  • Lower levels of fatigue are linked to higher intake of microbe-rich foods in adults aged 40 years or more.
  • Circulating 5-methyltetrahydrofolate is associated with reduced fatigue, highlighting the importance of folate.
  • Dietary patterns including live microbes enhance fatigue resilience, particularly when sufficient folate is present.
  • The findings support the nutrient-microbe pathway as vital for promoting healthy aging and reducing fatigue.

Abstract

Intake of microbe-rich foods and higher levels of circulating 5-methyltetrahydrofolate are both associated with lower levels of fatigue in midlife and older adults, and folate sufficiency appears to potentiate the fatigue-reducing benefits of live-microbe foods, supporting a nutrient-microbe pathway relevant to healthy aging.

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Cite This Study

Bigman et al. (2026) studied this question.

synapsesocial.com/papers/69a7607cc6e9836116a2d471https://doi.org/10.1016/j.maturitas.2026.108868
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