Interest in focused treatments for different types of osteoporosis has increased as a result of growing awareness of the liver, kidney, and bone interaction. Injury to the liver and kidneys caused by various disorders can disrupt bone metabolism, suggesting a new regulatory relationship among the liver, kidneys, and bones. But little is known about how the liver-bone center contributes to primary and secondary osteoporosis. Thus, investigating the precise regulatory motion of the liver-bone center may provide new curative strategies for the treatment of liver and bone disorders. Chronic liver disease is a prevalent health issue worldwide, especially in East Asia. Osteoporosis (OP), a prevalent metabolic bone disorder, has garnered heightened attention in ageing populations. In recent years, a growing association between osteoporosis and chronic kidney disease (CKD), belonging to the larger category of CKD-mineral and bone disease (CKD-MBD), has been noted. Changes in parathyroid hormone (PTH), vitamin D, calcium, and phosphorus metabolism are characteristics of CKD-MBD, which greatly increases the risk of fracture. This review aims to examine the correlation between chronic renal and liver illness and their effects on bone throughout the patient's lifespan.
Jebur et al. (2026) studied this question.