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March 3, 2026Frontiers in Pharmacology0 citationsOpen Access

Association of serum methylglyoxal with endothelial dysfunction in patients with type 2 diabetes

SYShanshan YuXJXinyan JinYXYuanying Xu

Key Points

  • Methylglyoxal levels significantly correlate with endothelial dysfunction in type 2 diabetes.
  • The study reports an inverse relationship between methylglyoxal and flow-mediated dilation metrics.
  • Assessment of serum levels utilized observational analysis among type 2 diabetes patients.
  • The findings highlight potential clinical applications for monitoring vascular health in diabetes.

Abstract

MGO was significantly inversely associated with FMD and endothelial function in T2DM patients, and can be used as a biomarker to assess vascular endothelial health. Detection of serum MGO levels has clinical significance in the prevention of early diabetic vascular disease.

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Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/69a76087c6e9836116a2d5aahttps://doi.org/10.3389/fphar.2026.1773149
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