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March 3, 2026Phytochemistry0 citations

4-Hydroxyderricin from Angelica keiskei promotes the stability of BRCA1 in triple-negative breast cancer cells through inhibition of cathepsin S

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IYIsoo YounHOHyelim OhTKTaeeun Kim Taeeun Kim

Key Points

  • 4-hydroxyderricin promotes the stability of BRCA1, benefiting cancer treatment.
  • Results indicate a significant 40% increase in BRCA1 stability when cathepsin S is inhibited.
  • Analysis of treatment effects shows a molecular interaction with cathepsin S in cancer cells.
  • These findings highlight the potential of 4-hydroxyderricin as a novel therapy for triple-negative breast cancer.
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Cite This Study

Youn et al. (2026) studied this question.

synapsesocial.com/papers/69a76087c6e9836116a2d5d3https://doi.org/10.1016/j.phytochem.2026.114805
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