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March 3, 2026International Immunopharmacology0 citations

Luteolin mitigates inflammatory organ injury by targeting XIAP to block PANoptosis and mitochondrial dysfunction

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FSFuli ShiYLYang-feng LvSLShi-qi Luo

Key Points

  • Luteolin effectively reduces inflammatory organ injury through the targeting of the XIAP pathway.
  • A significant decrease in injury markers was observed with luteolin treatment, suggesting its protective role.
  • The approach involves assessing the effects of luteolin on mitochondrial dysfunction and PANoptosis mechanisms.
  • This study highlights the potential of luteolin as a therapeutic agent against organ injury, warranting further investigation.
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Cite This Study

Shi et al. (2026) studied this question.

synapsesocial.com/papers/69a7608ec6e9836116a2d695https://doi.org/10.1016/j.intimp.2026.116271
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Luteolin Inhibits an Endotoxin-Stimulated Phosphorylation Cascade and Proinflammatory Cytokine Production in Macrophages2001 · 298 citations
  2. 2Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages2024 · 87 citations
  3. 3Blocking reverse electron transfer-mediated mitochondrial DNA oxidation rescues cells from PANoptosis2023 · 70 citations
  4. 4Role of Z-DNA Binding Protein 1 Sensing Mitochondrial Z-DNA and Triggering Necroptosis in Oxalate-Induced Acute Kidney Injury2024 · 17 citations
  5. 5Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis2023 · 178 citations