Our results suggest that the therapeutic effects of XQHF may be attributed to the synergistic actions of its multiple active constituents, which collectively suppress the inflammatory cascade and attenuate pyroptosis, thereby alleviating lung injury. Furthermore, both in vivo and in vitro experiments demonstrated that XQHF modulates sepsis-induced acute lung injury, at least in part, through the inhibition of the NLRP3/Caspase-1-dependent pyroptosis signaling pathway.
Lei et al. (2026) studied this question.