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March 3, 2026Frontiers in Cellular and Infection Microbiology0 citationsOpen Access

Hypercapnic acidosis affects in vitro lung infection response in a pathogen-specific manner

ECElena Campaña-DuelAAAina Areny‐BalagueróLMLuis Morales-Quinteros

Key Points

  • Lung inflammation is prolonged due to hypercapnic acidosis, impacting how the body fights infections.
  • Different pathogens are affected in various ways by hypercapnic acidosis, influencing their persistence in the lungs.
  • The compromised barrier function in the lungs results from prolonged exposure to hypercapnic acidosis.
  • Findings suggest that targeting the inflammatory response may improve outcomes in lung infections exacerbated by hypercapnia.

Abstract

HCA condition differentially influence host responses depending on the infectious pathogen, compromising the barrier function and prolonging lung inflammation with differences according to time culture, which could benefit bacterial persistence.

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Cite This Study

Campaña-Duel et al. (2026) studied this question.

synapsesocial.com/papers/69a760a5c6e9836116a2d975https://doi.org/10.3389/fcimb.2025.1708427
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