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March 3, 2026Frontiers in Immunology0 citationsOpen Access

Establishment of accurate estimation equations for area under the concentration curves using simultaneous limited sampling for extended-release tacrolimus and mycophenolic acid in kidney transplant recipients

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KMKyoko MinamisonoTNToshimasa NakaoTOTakehiro Ohyama

Key Points

  • The equation C0-C1-C3-C6 estimates both TAC-ER and MPA AUC accurately, showing strong correlation with R² over 0.95.
  • Validation demonstrates the efficacy of the LSS technique for estimating pharmacokinetics in a clinical setting.
  • This analysis supports the use of simultaneous limited sampling for effective medication monitoring in renal transplant patients.
  • Implementation of these estimation equations could reduce healthcare costs and improve patient management for kidney transplant recipients.

Abstract

Four equations (C0-C1-C6, C0-C1-C2-C6, C0-C1-C3-C6, C0-C1-C4-C6) showed strong correlations with the actual AUC (R² > 0.95), with the validation identifying C0-C1-C3-C6 as the most reliable for both TAC-ER and MPA. This study demonstrated that LSS using C0-C1-C3-C6 reliably and accurately estimated both the actual TAC-ER AUC0-24 and MPA AUC0-12 simultaneously in kidney transplant recipients. These equations can be feasibly implemented in outpatient clinical settings to reduce time and cost.

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Cite This Study

Minamisono et al. (2026) studied this question.

synapsesocial.com/papers/69a760aac6e9836116a2da17https://doi.org/10.3389/fimmu.2026.1710261
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