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March 3, 2026Experimental Gerontology0 citationsOpen Access

Correlation between sarcopenia and changes in oligodendrocyte lineage cells in the brains of Alzheimer's disease model mice

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LYLin-lin YaoXMXiao-ting MaFLFang-bo Li

Key Points

  • Neuroinflammation increases alongside sarcopenia in Alzheimer's model mice, indicating potential links between muscle health and brain pathology.
  • This study highlights a correlation where reduced oligodendrocyte progenitor cell (OPC) proliferation occurs with hindlimb immobilization-induced sarcopenia.
  • Analysis of brain tissue in Alzheimer’s disease model mice shows significant changes in oligodendrocyte lineage cells and muscle pathology.
  • Understanding the relationship between sarcopenia and brain cell changes may inform future therapeutic strategies for Alzheimer's disease.

Abstract

Hindlimb immobilization-induced sarcopenia correlated with slow-to-fast fiber transformation, reduced OPCs proliferation, and enhanced neuroinflammation. This study highlights the importance of sarcopenia in the progression of AD-related white matter pathology.

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Cite This Study

Yao et al. (2026) studied this question.

synapsesocial.com/papers/69a760aac6e9836116a2da18https://doi.org/10.1016/j.exger.2026.113057
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