Trace metal signatures in cerebrospinal fluid (CSF): Insights from an amyotrophic lateral sclerosis (ALS) hotspot on Mount Etna (Sicily, Italy)

Key Points

• Trace metal analysis highlights significant variations in cerebrospinal fluid samples from ALS patients.
• Levels of specific trace metals were found to be distinctly elevated in this ALS hotspot region.
• Analysis of cerebrospinal fluid samples from patients with ALS reveals patterns associated with neurodegeneration.
• These findings emphasize the potential role of environmental exposure to trace metals in ALS pathology.