Induced pluripotent stem cells (iPSCs) derived from cynomolgus monkey (crab-eating macaque) ear fibroblasts offer a minimally invasive and ethically acceptable source of cells for autologous therapies and preclinical research. Owing to close genetic and physiological similarities to humans, these iPSCs represent a relevant and versatile alternative to human-based models. Here, iPSCs exhibited trilineage differentiation and were directly differentiated into neurons in vitro, confirming pluripotency and neuronal potential. Validation tests confirmed chromosomal integrity, transgene clearance, and mycoplasma-free status. These findings highlight the potential of cynomolgus monkey iPSCs in advancing regenerative medicine, neuroscience research, and developing novel therapeutic strategies for neurodegenerative diseases.
An et al. (2026) studied this question.