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March 3, 2026The Journal of Nutritional Biochemistry

Guaiacol counters renal fibrosis via BMP/ERK/Smad1/5/9 signalling in UUO-induced chronic kidney disease

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Authors

HKHrushikesh Vikas KulkarniAGAnil Bhanudas Gaikwad

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Overview

Observational analysis shows guaiacol reduces renal fibrosis in kidney disease, suggesting potential therapeutic benefits.

Key Points

  • Renal fibrosis significantly decreased with guaiacol treatment, indicating its potential to reverse kidney damage.
  • Increased activation of BMP and ERK pathways was observed, highlighting important molecular targets.
  • Assessment using in vivo models of obstructive nephropathy demonstrated the role of Smad signaling in this effect.
  • Supports further exploration of guaiacol as a promising intervention for chronic kidney disease.

Cite This Study

Kulkarni et al. (2026) studied this question.

synapsesocial.com/papers/69a76186c6e9836116a2f896https://doi.org/10.1016/j.jnutbio.2026.110317
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