Protection mechanism of epalrestat on glutamate-induced retinal excitotoxicity model based on network pharmacology

Key Points

• Epalrestat reduces glutamate-induced retinal excitotoxicity, offering neuroprotection.
• The analysis indicates a significant reduction in cell death and inflammation markers.
• Analysis using network pharmacology identified multiple protective pathways for epalrestat.
• The findings suggest potential therapeutic applications but require further validation in clinical settings.