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March 8, 2026Acta Biochimica et Biophysica Sinica0 citationsOpen Access

Structural Insights Into DNA Recognition Mechanisms of TerS in Cyanophages

Structural and functional insights into the distinct DNA recognition mechanisms of the terminase small subunit TerS from cyanophages

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Authors

DDDe-Qin DongFYFeng YangKDKang Du

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Overview

This research reveals distinct DNA recognition strategies in cyanophages, highlighting evolutionary mechanisms.

Key Points

  • The study aims to investigate the molecular mechanisms by which TerS recognizes DNA in cyanophages.
  • Utilized cryo-electron microscopy to determine the structure of TerS from cyanophage Pam5.
  • Conducted biochemical assays to examine DNA binding strategies of TerS.
  • Compared DNA recognition methods between two cyanophage TerS proteins.
  • Cryo-electron microscopy revealed a nonameric ring structure of Pam5 TerS.
  • Pam5 TerS specifically recognizes a 21-bp DNA sequence via its N-terminal helix-turn-helix domain.
  • Pam1 TerS was found to bind DNA in a sequence-independent manner, indicating distinct recognition strategies.

Cite This Study

Dong et al. (2026) studied this question.

synapsesocial.com/papers/69ada873bc08abd80d5bb5f2https://doi.org/10.3724/abbs.2026042
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