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March 8, 2026

Unveiling the risk: A comprehensive analysis of drug-induced aphthous ulcers using real-world data from FAERS.

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Authors

FYFei YeYHYingxue HuangYZYanbo Zhang

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Overview

Analysis reveals significant risk factors for drug-induced aphthous ulcers, highlighting the need for vigilant management.

Key Points

  • The study aims to explore the connection between medications and drug-induced aphthous ulcers using FAERS data.
  • Analyzed adverse event reports from the FDA's FAERS from Q3 2015 to Q4 2024.
  • Employed disproportionality analysis and Bayesian neural network algorithms.
  • Conducted univariate and multivariate logistic regression analyses to identify risk factors.
  • Identified 426 medications linked to aphthous ulcers in FAERS.
  • Disproportionality analysis revealed 26 drugs with significant risk, including infliximab and methotrexate.
  • Confirmed that the top 5 drugs were independent risk factors for drug-induced aphthous ulcers.

Cite This Study

Ye et al. (2026) studied this question.

synapsesocial.com/papers/69ada873bc08abd80d5bb79ahttps://doi.org/10.1097/md.0000000000047844
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