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March 8, 2026

Molecular and Antiangiogenic Effects of Paclitaxel-Loaded Nanoparticles: Influence of the Nanocarrier Type.

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Authors

JPJulia Sapienza PassosGMGiovanna Barros de MeloGSGiovanna Cassone Salata

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Overview

Demonstrates how nanoparticle type influences drug effectiveness and safety in breast cancer, suggesting improved treatment approaches.

Key Points

  • The aim is to investigate the effects of different nanoparticle types on the efficacy and biological activity of paclitaxel in breast cancer cells.
  • Developed nanostructured lipid carriers (NLCs) and lipid-polymeric hybrid nanoparticles (H-NPs) for paclitaxel delivery.
  • Assessed apoptosis and DNA damage in breast cancer cell lines, including MCF-7 and MDA-MB-231.
  • Examined antiangiogenic effects in the chicken chorioallantoic membrane model.
  • NLC-PTX induced greater α-tubulin acetylation and DNA damage compared to H-NP-PTX.
  • Paclitaxel as a solution caused lesser effects than the nanoencapsulated forms in terms of cytotoxicity.
  • Nanoencapsulation lowered irritation while maintaining significant antiangiogenic activity, achieving 6.1-7.8-fold vessel growth inhibition.

Cite This Study

Passos et al. (2026) studied this question.

synapsesocial.com/papers/69ada885bc08abd80d5bb807https://doi.org/10.1021/acs.molpharmaceut.5c01740
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