Demonstrates the role of lipid-associated epigenetic markers in tissue identity and aging in mammals, suggesting evolutionary conservation.
Key Points
The research aims to determine whether lipid-associated epigenetic markers are conserved across mammals and how they relate to tissue identity and aging.
Identified lipid-associated CpG sites using the Korean Genome and Epidemiology Study cohort
Projected findings onto the Mammalian Methylation Consortium dataset
Analyzed evolutionary conservation, tissue specificity, and age-related dynamics
Examined phylogenetic patterns in blood and three metabolic organs across five mammalian species
Lipid-related CpG sites were found to be highly conserved across various mammals
t-SNE analysis clustered samples based on tissue identity and species
Significant correlations were observed between methylation levels of CpGs and lifespan
High phylogenetic concordance existed between blood profiles and key metabolic organs
Patterns of lipid epigenetics were consistent across sexes