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March 8, 2026Cureus0 citationsOpen Access

Metastatic Prostate Adenocarcinoma Mimicking Multifocal Periapical Pathosis

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PEPinar Emecen-HujaTWTina R WoodsPSPerry J Stamatiades

Key Points

  • To highlight how metastatic prostate adenocarcinoma can mimic periapical pathology in imaging studies of the jaw.
  • Routine radiographic examination of the mandible
  • Histopathologic examination of jaw lesions
  • Lesions appeared as well-defined radiolucencies at the apex of non-vital teeth
  • Initial imaging suggested periapical pathology, but histopathology confirmed metastatic adenocarcinoma

Abstract

The jaw is an uncommon site for metastasis, accounting for 1% of all oral cancers. The posterior mandible is the most common site of metastatic deposits, which typically present as ill-defined radiolucency. We present a case of metastatic prostate adenocarcinoma found during routine radiographic examination, resembling that of periapical pathology bilaterally in the mandible. The lesions presented as well-defined radiolucencies at the apex of non-vital teeth. Both lesions were revealed to be metastatic adenocarcinoma during histopathologic examination, emphasizing the importance of including malignant neoplasm in the differential diagnosis.

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Cite This Study

Emecen-Huja et al. (2026) studied this question.

synapsesocial.com/papers/69ada8b2bc08abd80d5bbf25https://doi.org/10.7759/cureus.104778
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