Associations of genetically predicted interleukin-6 and tumor necrosis factor signaling pathways with mortality among persons with colorectal cancer: a two-sample Mendelian randomization
This research examines how genetically predicted interleukin-6 and tumor necrosis factor signaling pathways associate with mortality in colorectal cancer.
Used two-sample Mendelian randomization to analyze genetic data
Evaluated associations between IL-6 and TNF-related pathways and colorectal cancer outcomes
Investigated mortality rates among colorectal cancer patients
IL-6 signaling is associated with colorectal cancer progression, albeit limited
TNF-related pathways show less relevance for prognosis in colorectal cancer cases
Abstract
Our findings suggest that IL-6 signaling may play a role in CRC progression although of limited magnitude, whereas TNF-related pathways appear less relevant for prognosis.