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March 8, 2026PLoS ONE0 citationsOpen Access

PAH-former: Transfer learning for efficient discovery of pulmonary arterial hypertension-associated genes

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TKToshinaru KawakamiSHS. HosokawaMIMasamichi Ito

Key Points

  • The aim is to develop a platform for efficient discovery of genes linked to pulmonary arterial hypertension.
  • Developed a transfer learning model called PAH-former.
  • Utilized limited data for identification of candidate genes.
  • Applied the model for mechanistic insights into disease pathways.
  • Enabled the identification of new candidate genes for PAH.
  • Showed promise for accelerating therapeutic development.
  • Provided insights into cell-specific mechanisms of the disease.

Abstract

Our novel platform, PAH-former, provides a powerful and broadly applicable strategy for disease-related gene discovery. This approach enables the identification and validation of new candidate genes from limited data, promising to advance cell-specific mechanistic insights and accelerate therapeutic development for rare diseases like PAH. (248/300 words).

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Cite This Study

Kawakami et al. (2026) studied this question.

synapsesocial.com/papers/69ada90bbc08abd80d5bc5a2https://doi.org/10.1371/journal.pone.0344084
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