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March 8, 2026Science Immunology0 citations

IgG4 on the dance floor: Partners swapped by Fab-arm exchange

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AGAilis GrieshaberKOKevin C. O’Connor

Key Points

  • This research aims to explore the processes and implications of Fab-arm exchange in IgG4 antibodies.
  • Conducted proteomic analysis of circulating IgG4 antibodies.
  • Identified occurrence and extent of Fab-arm exchange.
  • Characterized the bispecific antibody repertoire generated.
  • Nearly all circulating human IgG4 undergoes Fab-arm exchange.
  • A vast bispecific antibody repertoire is created through this process.

Abstract

Proteomic analysis shows that nearly all circulating human IgG4 undergoes Fab-arm exchange, creating a vast bispecific antibody repertoire.

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Cite This Study

Grieshaber et al. (2026) studied this question.

synapsesocial.com/papers/69ada962bc08abd80d5bca55https://doi.org/10.1126/sciimmunol.aeg6827
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