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March 8, 2026PLoS ONE1 citationsOpen Access

The impact of the COVID-19 pandemic on oral anticoagulation adherence in patients with atrial fibrillation managed in primary care: Results from the PRIME Registry

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OAOmer AtacVAVolkan AydinLPLars E. Peterson

Key Result

The COVID-19 pandemic led to sustained declines in oral anticoagulation adherence and persistence in atrial fibrillation patients in primary care.

Key Points

  • To investigate the influence of the COVID-19 pandemic on adherence to oral anticoagulation in patients with atrial fibrillation in primary care.
  • Analysis of data from the PRIME Registry
  • Assessment of adherence rates before and during the pandemic
  • Identification of high-risk subgroups for targeted intervention
  • Sustained declines in adherence to oral anticoagulants among AF patients
  • Need for telemedicine and home-based care interventions identified
  • Highlighted importance of addressing high-risk patient subgroups for improved care

Structured PICO

Does the COVID-19 pandemic affect oral anticoagulation adherence in patients with atrial fibrillation managed in primary care?

P
Population
Patients with atrial fibrillation managed in primary care (from the PRIME Registry)
I
Intervention
COVID-19 pandemic (exposure)
O
Outcome
Oral anticoagulation (OAC) adherence and persistence

The COVID-19 pandemic caused sustained declines in oral anticoagulation adherence among primary care atrial fibrillation patients, highlighting the need for targeted interventions like telemedicine during public health crises.

Abstract

The COVID-19 pandemic was associated with sustained declines in OAC adherence and persistence among AF patients in primary care. Targeted interventions including telemedicine, home-based care, and attention to high-risk subgroups are essential to maintain continuity of care and improve adherence during public health crises.

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Cite This Study

Atac et al. (2026) studied this question. The COVID-19 pandemic led to sustained declines in oral anticoagulation adherence and persistence in atrial fibrillation patients in primary care.

synapsesocial.com/papers/69ada962bc08abd80d5bcb0chttps://doi.org/10.1371/journal.pone.0344020
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