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March 12, 2026Toxics0 citationsOpen Access

PPARα Antagonism Mitigates Chlorpyrifos-Induced Neuro-Visual Toxicity in Zebrafish Larvae

PPARα Antagonism Rescues Chlorpyrifos-Induced Neuro-Visual Toxicity in Zebrafish (Danio rerio) Larvae

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Authors

YJYuyao JiangZDZijie DingRHRuolin Hu

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Overview

Reveals PPARα antagonism rescues neuro-visual impairments in zebrafish larvae exposed to chlorpyrifos, suggesting therapeutic implications.

Key Points

  • To determine the effects of chlorpyrifos on neuro-visual development in zebrafish larvae and evaluate the role of PPARα signaling.
  • Zebrafish larvae were exposed to varying concentrations of chlorpyrifos and a vehicle control.
  • Behavioral assays measured swimming activity during light and dark periods.
  • Transcriptomic profiling assessed gene expression related to nervous and vision function.
  • Metabolomics measured levels of key neurotransmitters.
  • Histological analysis evaluated retinal structure.
  • High chlorpyrifos concentrations significantly reduced motor activity.
  • Dopamine and GABA levels increased, indicating neurotransmitter dysregulation.
  • Neuronal fluorescence decreased in exposed larvae.
  • Retinal injury was observed with reduced photoreceptor layer thickness.
  • PPARα antagonism improved behavioral deficits and normalized neurotransmitter levels.

Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/69b258a396eeacc4fcec86ffhttps://doi.org/10.3390/toxics14030234
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