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March 16, 2026ACS Applied Polymer Materials

Smart Hybrid Nanocontainers: Layered Double Hydroxide Nanoparticles Modified with Thermoresponsive Polymers

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Authors

DBDariana Aristizábal BedoyaMMMicaela A. MacchioneMSMiriam C. Strumia

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Overview

This research develops smart hybrid nanocontainers for drug delivery, demonstrating improved stability and controlled release in a laboratory setting.

Key Points

  • The aim is to develop smart hybrid nanocontainers for efficient drug delivery using layered double hydroxides and thermoresponsive polymers.
  • Synthesis of layered double hydroxide nanoparticles intercalated with methotrexate.
  • Functionalization of nanoparticles with terminal vinyl groups.
  • Free-radical polymerization assisted by ultrasound to fabricate thermoresponsive nanohybrids.
  • Assessment of the colloidal stability and thermoresponsive behavior of hybrid nanocontainers.
  • Incorporation of the smart polymer significantly enhances colloidal stability and dispersibility.
  • Controlled drug release of methotrexate is achieved, especially when loaded before polymerization.
  • The developed hybrid nanocontainers demonstrate stability and thermoresponsive characteristics.

Cite This Study

Bedoya et al. (2026) studied this question.

synapsesocial.com/papers/69b79dce8166e15b153aafbchttps://doi.org/10.1021/acsapm.5c04783
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