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March 16, 2026Journal of Orthopaedic Surgery and ResearchOpen Access

Third-generation cryotherapy reduces time to surgery and local complications in patients with ankle fractures: a prospective randomised controlled trial

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Authors

RLRiccardo Maria LanzettiAVAlessio Giai ViaFAFrancesco Anzano

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Overview

A randomized controlled trial shows cryotherapy reduces surgery time and complications in ankle fracture patients, suggesting it as an effective treatment option.

Key Points

  • This research aims to evaluate the effectiveness of third-generation cryotherapy in managing ankle fractures, focusing on surgery timing and local complications.
  • Randomised controlled trial with 169 patients having ankle fractures.
  • Participants were divided into a cryotherapy group (89 patients) and a control group (80 patients).
  • Measured outcomes included time to surgery, pain levels (VAS), opioid intake, and skin complications.
  • Mean time to surgery was significantly shorter in the cryotherapy group (34.78 hours) versus the control (91.44 hours, p < 0.001).
  • Cryotherapy group showed lower mean VAS scores (2.04) compared to the control group (5.9).
  • Less morphine consumption was recorded in the cryotherapy group (0.1 mg) compared to controls (0.83 mg).
  • Only 4.5% of the cryotherapy patients developed skin complications versus 28.7% in the control group.

Cite This Study

Lanzetti et al. (2026) studied this question.

synapsesocial.com/papers/69b79e7c8166e15b153abebbhttps://doi.org/10.1186/s13018-025-06599-x
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