The aim is to evaluate how flunixin meglumine affects the pharmacokinetics of enrofloxacin and marbofloxacin in preweaning calves.
Administer flunixin meglumine alongside enrofloxacin and marbofloxacin to preweaning calves.
Measure and compare drug elimination rates and efficacy.
Analyze the pharmacokinetic profiles of both antibiotics after treatment.
Flunixin significantly prolongs the elimination time of enrofloxacin and marbofloxacin.
No compromise in estimated efficacy of the antibiotics observed.
Specific optimization may be necessary for targeting certain respiratory disease pathogens.
Abstract
Flunixin prolongs elimination of enrofloxacin and marbofloxacin without compromising estimated efficacy, although optimisation may be required for some bovine respiratory disease pathogens.