The research aims to identify predictors of infection risk in childhood systemic lupus erythematosus patients undergoing treatment with belimumab.
Analyzed the effects of belimumab on B cell depletion and immunoglobulin G levels.
Developed a nomogram for risk stratification based on early B cell and IgG changes.
Profound B cell depletion is associated with a higher infection risk.
Significant reduction in IgG levels correlates with increased susceptibility to infections.
The nomogram serves as a practical tool for monitoring and risk assessment.
Abstract
Early, profound B cell depletion and IgG reduction are key predictors of infection in belimumab-treated cSLE. Our nomogram provides a practical tool for risk stratification and personalized monitoring.